Cryptic Production of trans -3-Hydroxyproline in Echinocandin B Biosynthesis
نویسندگان
چکیده
منابع مشابه
Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli
BACKGROUND Trans-4-hydroxy-L-proline (trans-Hyp), one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals. Although there are some natural biosynthetic pathways of trans-Hyp existing in microorganisms, the yield is still too low to be scaled up for industrial applications. Until now the production of trans-Hyp is mainly from the acid ...
متن کاملsynthesis of 3-aryl-2h-benzo[b]-1,4-oxazines in [omim]bf4 and reduction of organic compounds in methylimidazolium formate
در این پروژه ترکیبات 3-آریل-2h-بنزو[b]-4،1-اکسازین ها از مواد اولیه تجاری مشتقات دو آمینو فنول و ?-هالو کتون های آروماتیک در مایع یونی 1-اکتیل-3-متیل ایمیدازولیوم تترا فلورو بورات([omim]bf4) سنتز شده است. این واکنش توسط باز پتاسیم کربنات محلول از طریق o-آلکیلاسیون و سپس یک واکنش آمیداسیون درون مولکولی خود بخود در مدت زمان کوتاه انجام می شود. ترکیبات 4،1-بنزوکسازین به این روش با بهره خوب تا آلی ...
15 صفحه اولConversion of Proline-14c to Collagen Trans-3-hydroxyproline-14c in the Chick Embryo.
trans-3-Hydroxy-nn-proline-3,4-3H was synthesized by reduction of N-carbobenzoxy-3-keto-DLproline methyl ester with NaBH4 (4). Uniformly labeled n-proline-r4C was obtained from New England Nuclear Corporation. Uniformly labeled 4-hydroxy-r.-prolineJ4C was generously donated to us by Dr. Chozo Mitoma. Seven-day-old chick embryos were obtained from the Duckworth Hatchery (Elkridge, Maryland) and ...
متن کاملHeterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis
Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a nonadride) and agnestadride A (a heptadride) was investigated through gene disruption and heterologous expression experiments. The results reveal that the precursors for cyclization...
متن کاملStudies on 3-methoxyproline and 3-hydroxyproline.
The cis and trans racemates of synthetic 3-hydroxyproline and of synthetic 3-methoxyproline were interconverted by an epimerization reaction at carbon atom 2. The interconversions are proof of the diastereomeric nature of the synthetic isomers. Assignments of cis and trans configuration were made from nuclear magnetic resonance studies. Synthetic cisand trans-3-hydroxy-DL-proline were partially...
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ژورنال
عنوان ژورنال: Applied and Environmental Microbiology
سال: 2018
ISSN: 0099-2240,1098-5336
DOI: 10.1128/aem.02370-17